Quantitative phenotype characterization of developing mouse brains by diffusion tensor imaging: Application for the Frizzled- 4-/- mutant mice
نویسندگان
چکیده
Fig. 2: Population-averaged FA differences in the dentate gyrus of Fz4 and WT mouse brains. Left ) Coronal semisections from WT (right) and Fz4 brains at P7, P14 and P30. Right) FA difference maps (FAWT FA Fz4-/-). White arrows indicate regions of higher FA in the dentate gyrus of Fz4-/brains. Quantitative phenotype characterization of developing mouse brains by diffusion tensor imaging: Application for the Frizzled4-/mutant mice
منابع مشابه
Three-dimensional anatomical characterization of the developing mouse brain by diffusion tensor microimaging.
Investigation of three-dimensional (3D) morphometry of developing brains has been hindered by a lack of imaging modalities that can monitor the 3D evolution of various anatomical structures without sectioning and staining processes. In this study, we combined magnetic resonance microimaging and diffusion tensor imaging techniques to accomplish such visualization. The application of this approac...
متن کاملThe Benefits and implementations of Diffusion tensor imaging and Neural Fiber Tractography in Brain Surgery
Background and Aim: The methods for detecting brain activation with fMRI, MRI provides a way to measure the anatomical connections which enable lightning-fast communication among neurons that specialize in different kinds of brain functions. Diffusion tensor imaging is able to measure the direction of bundles of the axonal fibers which are all aligned. Besides mapping white matter fiber tracts,...
متن کاملMapping postnatal mouse brain development with diffusion tensor microimaging.
While mouse brain development has been extensively studied using histology, quantitative characterization of morphological changes is still a challenging task. This paper presents how developing brain structures can be quantitatively characterized with magnetic resonance diffusion tensor microimaging coupled with techniques of computational anatomy. High resolution diffusion tensor images of ex...
متن کاملEvaluation of White Matter Tracts in Autistic Individuals: A Review of Diffusion Tensor Imaging Studies
Introduction: Many cognitive and social deficits in autism are caused by abnormal functional connections between brain networks, which are manifested by impaired integrity of white matter tracts. White matter tracts are like the "highways" of the brain, which allow fast and efficient communication in different areas of the brain. The purpose of this article is to review the results of autism st...
متن کاملAn MRI-based atlas and database of the developing mouse brain
The advent of mammalian gene engineering and genetically modified mouse models has led to renewed interest in developing resources for referencing and quantitative analysis of mouse brain anatomy. In this study, we used diffusion tensor imaging (DTI) for quantitative characterization of anatomical phenotypes in the developing mouse brain. As an anatomical reference for neuroscience research usi...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2008